Tumor Fusion Gene Data Portal
Landscape of cancer-associated fusions using the Pipeline for RNA sequencing Data Analysis
Transcripts fusion as a result of genomic rearrangement is an important class of somatic alteration, as a cancer initiating event and as a molecular therapeutic target for specific tumors. Our Pipeline for RNA sequencing Data Analysis (PRADA) enables us to detect fusion transcripts with high confidence comprehensively. Based on integrated analysis of paired-end RNA sequencing and DNA copy number data from The Cancer Genome Atlas(TCGA), The Tumor Fusion Gene Data Portal provides a bona-fide fusion list across many tumor types.
Figure 1. Fusion transcripts:
Fusion transcripts are chimeric mRNAs encoded from the joined parts of two genes, and may occur as a result of genomic rearrangements.
Figure 2. Detection of fusion transcripts.
PRADA detects fusion transcripts through identification of discordant read pairs and junction spanning reads.
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