Fusion 'PAK1'-'SHANK2' in BRCA
5'Gene 3'Gene
Gene Name PAK1 SHANK2
Chromosome 11 11
Strand -1 -1
Breakpoint position 77184597 70507783
Discordant read pairs 48
Junction spanning reads 44
Perfect Junction spanning reads 43
BLAST E value 0.098
Tier tier1
Frame 5UTR-CDS
Centrality 0.38168
SampleId TCGA.XX.A899.01A
Validated by WGS NA

Fig. The gene expression correlation between fused genes

5' Gene p21 (RAC1) activated kinase 1 [Source:HGNC Symbol;Acc:HGNC:8590]
3' Gene SH3 and multiple ankyrin repeat domains 2 [Source:HGNC Symbol;Acc:HGNC:14295]

Per the recommendation of the HUGO Gene Nomenclature Committee for Gene Fusion Designation, gene fusions are now annotated as "Gene A::Gene B". Please note that the nomenclature in the image below predates these recommendations.


Fig. Exon expression plot for fused genes. Expression was normalized across all exons; blue = lowest expression, red = highest expression. Line indicates where genes are connected.