Fusion 'KLHDC4'-'SPG7' in BRCA
5'Gene 3'Gene
Gene Name KLHDC4 SPG7
Chromosome 16 16
Strand -1 1
Breakpoint position 87782279 89611056
Discordant read pairs 7
Junction spanning reads 10
Perfect Junction spanning reads 10
BLAST E value 2.6
Tier tier1
Frame Out-of-frame
Centrality 0.37712
SampleId TCGA.C8.A1HN.01A
Validated by WGS NA

Fig. The gene expression correlation between fused genes

5' Gene kelch domain containing 4 [Source:HGNC Symbol;Acc:HGNC:25272]
3' Gene SPG7, paraplegin matrix AAA peptidase subunit [Source:HGNC Symbol;Acc:HGNC:11237]

Per the recommendation of the HUGO Gene Nomenclature Committee for Gene Fusion Designation, gene fusions are now annotated as "Gene A::Gene B". Please note that the nomenclature in the image below predates these recommendations.


Fig. Exon expression plot for fused genes. Expression was normalized across all exons; blue = lowest expression, red = highest expression. Line indicates where genes are connected.