Fusion 'ERBB2'-'CDK12' in BRCA
5'Gene 3'Gene
Gene Name ERBB2 CDK12
Chromosome 17 17
Strand 1 1
Breakpoint position 37868701 37680927
Discordant read pairs 175
Junction spanning reads 94
Perfect Junction spanning reads 75
BLAST E value 0.41
Tier tier1
Frame In-frame
Centrality 0.38259
SampleId TCGA.BH.A204.01A
Validated by WGS NA

Fig. The gene expression correlation between fused genes

5' Gene erb-b2 receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:3430]
3' Gene cyclin dependent kinase 12 [Source:HGNC Symbol;Acc:HGNC:24224]

Per the recommendation of the HUGO Gene Nomenclature Committee for Gene Fusion Designation, gene fusions are now annotated as "Gene A::Gene B". Please note that the nomenclature in the image below predates these recommendations.


Fig. Exon expression plot for fused genes. Expression was normalized across all exons; blue = lowest expression, red = highest expression. Line indicates where genes are connected.